Though coming off an impressive win in Cleveland the night before, the loss marks the fourth loss in five games.
Ryan Anderson led the way for the Pelicans with 18 points off 7-17 shooting from the field and 9 rebounds, followed by Anthony Davis with 16 points off 8-21 shooting with 6 rebounds.
The Pelicans as a team shot 41.1 percent from the field and 30.8 percent from behind the arc the compared to the Celtics 49.4 percent from the floor and 42.9 percent from deep, respectively.
Tyreke Evans had a tough game, scoring a goose egg, missing all five of his shot attempts, notching three assists.
The Pelicans next play the depleted Washington Wizards Friday at the Smoothie King Center at 7pm. The Wiz squeaked out a win in Miami with Jared Dudley playing center most of the fourth quarter,